We seek one highly motivated individual with a strong interest in pursuing a PhD degree in medical biochemistry with specialization in tumor biology and within a research program at UppsalaUniversity. The project focuses on the signal transduction pathways of transforming growth factor beta (TGFbeta) and liver kinase B1 (LKB1), with the central aim to understand physiological processes that implicate the two pathways and which control the capacity of tumor cells to differentiate and invade its microenvironment.Tranforming growth factor beta (TGFbeta) and LKB1 guide major tumor suppressor pathways in a variety of human tissues. Our laboratory has established mechanisms of crosstalk between these pathways in regulation of cell proliferation, invasion and epithelial-mesenchymal transition (EMT). LKB1 acts directly on specific members of the Smad family that transmits TGFbeta signals. LKB1 also acts by activating the kinase activity of the AMP-regulated kinase family (AMPK), members of which are the salt-inducible kinase (SIK) and Nuak2. The new project will attempt to explain how LKB1 functions via SIK and Nuak2 activation to regulate TGFbeta signaling, epithelial cell polarity and protein synthesis.
-The person we seek must possess a M.Sc. degree in Biochemistry, Biomedicine, Molecular Biology or a related field. -She/he should have a strong interest and general skills in cell biology, biochemistry, and molecular biology. -Depending on your basic education and/or your background, additional education at the institution may be obtained in the specific area of research. -To be employed as a PhD student, the candidate needs to be accepted for registration at the postgraduate program. -Acceptance for registration at the postgraduate program will depend on the PhD candidate’s ability to undertake a research project. -Guidelines for PhD student employment can be found in Högskoleförordningen 5 kap 1-7 §§