Applications are invited for a post-doctoral research associate to work with Professor Chris Abell and Professor Tom Blundell (Department of Biochemistry) using fragment-based approaches to discover molecules that inhibit enzymes from Mycobacterium tuberculosis (see Angew. Chemie Intl. Ed. 2009, 48, 8452-8456 for an example of our work). The project will involve the synthesis of enzyme inhibitors using fragment-based approaches, and is part of a larger drug discovery initiative.
Applicants should have (or be about to obtain) a PhD in organic chemistry. Proven expertise in synthetic organic chemistry is essential; some knowledge of enzymology and drug discovery would be advantageous.